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Original ArticleOpen Access
Alleviation of the Climacteric Symptoms with Oral Sequential Hormone Replacement Therapy
Chittacharoen A 
,
Domhardt R ,
Manonai J ,
Theppisai U ,
Golbs S
,
Domhardt R ,
Manonai J ,
Theppisai U ,
Golbs S REINER DOMHARDT, Ing**,
URUSA THEPPISAI, MD*,
The efficacy of the oral hormone replacement therapy (HRT) preparation estradiol valerate/
levonorgestrel (EVILNG, KlimonormเธŽ) in the alleviation of the menopausal complaints of peri-and
postmenopausal Thai women was studied in a prospective, open, uncontrolled phase IV clinical trial.
Of the 50 peri-or postmenopausal women screened, 39 completed the study. From them 31 were post-
menopausal and 8 peri menopausal. The participants received EV /LNG over a period of 6 cycles. The
Menopause Rating Scale II (MRS II) was used to assess the effect of EV/LNG on the menopausal
symptoms.
The changes in the main parameters of the MRS II during the treatment with EV !LNG showed
that the general score decreased by 34.9 per cent after 3 months and was kept at the same value after
6 months of treatment. The somata-vegetative complaints decreased by 32.5 per cent after 3 months
and by 35 per cent after 6 months. The pJ>ychological complaints decreased by 34.1 per cent after 3
months and by 32.9 per cent after 6 months. The urogenital complaints decreased by 29.3 per cent after
3 months, and remained at the same level after 6 months of treatment. In conclusion, the 6-months
administration of the oral HRT preparation estradiol valerate/levonorgestrel caused a considerable
alleviation of the climacteric symptoms in menopausal women.
Key word : Climacteric Symptoms, Menopause, Hormone Replacement Therapy, Estradiol Valerate/
Levonorgestrel
URUSA THEPPISAI, MD*,
The efficacy of the oral hormone replacement therapy (HRT) preparation estradiol valerate/
levonorgestrel (EVILNG, KlimonormเธŽ) in the alleviation of the menopausal complaints of peri-and
postmenopausal Thai women was studied in a prospective, open, uncontrolled phase IV clinical trial.
Of the 50 peri-or postmenopausal women screened, 39 completed the study. From them 31 were post-
menopausal and 8 peri menopausal. The participants received EV /LNG over a period of 6 cycles. The
Menopause Rating Scale II (MRS II) was used to assess the effect of EV/LNG on the menopausal
symptoms.
The changes in the main parameters of the MRS II during the treatment with EV !LNG showed
that the general score decreased by 34.9 per cent after 3 months and was kept at the same value after
6 months of treatment. The somata-vegetative complaints decreased by 32.5 per cent after 3 months
and by 35 per cent after 6 months. The pJ>ychological complaints decreased by 34.1 per cent after 3
months and by 32.9 per cent after 6 months. The urogenital complaints decreased by 29.3 per cent after
3 months, and remained at the same level after 6 months of treatment. In conclusion, the 6-months
administration of the oral HRT preparation estradiol valerate/levonorgestrel caused a considerable
alleviation of the climacteric symptoms in menopausal women.
Key word : Climacteric Symptoms, Menopause, Hormone Replacement Therapy, Estradiol Valerate/
Levonorgestrel
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