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Original ArticleOpen Access
Mammographic Change in Hysterectomized Women on 0.625 mglday of Conjugated Equine Estrogen
Panpanit A 
,
Muttarak M ,
Pongsatha S ,
Chaovisitsaree S ,
Piyamongkol W ,
Truengthawatchai S ,
Morakot N ,
Sribanditmongkol N ,
Noium S ,
Churith K ,
Chuntaranikul M
,
Muttarak M ,
Pongsatha S ,
Chaovisitsaree S ,
Piyamongkol W ,
Truengthawatchai S ,
Morakot N ,
Sribanditmongkol N ,
Noium S ,
Churith K ,
Chuntaranikul M MALA I MUTTARAK, MD**,
SOMSAK CHAOVISITSAREE, MD*,
SOMPONG TRUENGTHAWATCHAI, MD*,
NARISA SRIBANDITMONGKOL, BSc*,
KUNNIKA CHURITH, BSc*,
Objective : To compare the mammographic change before and after conjugated equine
estrogen (CEE) 0.625 mg/day in hysterectomized women.
Design: A retrospective descriptive study.
Setting : Menopause clinic, Maharaj Nakorn Chiang Mai Hospital.
Material and Method : Dedicated mammograms and demographic data of 66 women who
had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study.
CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the
initiation of HRT and they were compared with the follow-up mammography performed 12-18 months
after therapy. The degree of increase in mammographic density was classified as follows: minimal
changes (10-25% increased density), moderated change (26-50% increased density), and marked change
(>50% increased density).
Results: The mean ageเธ‘ SD was 47 เธ‘ 4.3 years old. The mean durationเธ‘ SD of hormone
used was 13.5 เธ‘ 2.4 months. The most common indication for operation was myoma uteri (43.9%). On
the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass
suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to
have significantly increased breast density. One was moderately increased and the other was markedly
increased, but cystic changes and one fibroadenoma were not changed.
Conclusion: CEE has little effect on increased mammographic density.
Key word : Mammographic Change, Hysterectomized Women, Hormone Replacement Therapy
SOMSAK CHAOVISITSAREE, MD*,
SOMPONG TRUENGTHAWATCHAI, MD*,
NARISA SRIBANDITMONGKOL, BSc*,
KUNNIKA CHURITH, BSc*,
Objective : To compare the mammographic change before and after conjugated equine
estrogen (CEE) 0.625 mg/day in hysterectomized women.
Design: A retrospective descriptive study.
Setting : Menopause clinic, Maharaj Nakorn Chiang Mai Hospital.
Material and Method : Dedicated mammograms and demographic data of 66 women who
had been hysterectomized were reviewed. Post surgical menopausal women were recruited for the study.
CEE 0.625 mg/day was given just after the operation. The baseline mammography was done before the
initiation of HRT and they were compared with the follow-up mammography performed 12-18 months
after therapy. The degree of increase in mammographic density was classified as follows: minimal
changes (10-25% increased density), moderated change (26-50% increased density), and marked change
(>50% increased density).
Results: The mean ageเธ‘ SD was 47 เธ‘ 4.3 years old. The mean durationเธ‘ SD of hormone
used was 13.5 เธ‘ 2.4 months. The most common indication for operation was myoma uteri (43.9%). On
the baseline mammogram, 5 cases had cystic change and one case had a small circumscribed solid mass
suspected to be fibroadenoma. On the follow-up mammograms, there were 2 cases (3.0%) detected to
have significantly increased breast density. One was moderately increased and the other was markedly
increased, but cystic changes and one fibroadenoma were not changed.
Conclusion: CEE has little effect on increased mammographic density.
Key word : Mammographic Change, Hysterectomized Women, Hormone Replacement Therapy
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