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Original ArticleOpen Access
Effect of Fish Oil on Oxidative Stress, Lipid Profile and Renal Function in IgA Nephropathy
Parinyasiri U 
,
OngAjyooth L ,
Parichatikanond P ,
OngAjyooth S ,
Liammongkolkul MS ,
Kanyog S
,
OngAjyooth L ,
Parichatikanond P ,
OngAjyooth S ,
Liammongkolkul MS ,
Kanyog S LEENA ONG-AJYOOTH, MD*,
SOMPONG ONG-AJYOOTH, MS***,
SURIN KANYOG, MS***
The omega-3 polyunsaturated fatty acids in fish oil have been shown to produce beneficial
effects, such as a reduction in blood pressure, proteinuria, lipid levels and inflammation. Aggregated
immunoglobulin A obtained from lgA nephropathy patients induced greater oxygen free radicals in
polymorphonuclear leukocytes than other glomerulopathy. All of which may affect the course of lgA
nephropathy.
Twenty-three adult patients with biopsy proven lgA nephropathy, with proteinuria more than
I g/day, serum creatinine less than 3 mg/dl and blood pressure control less than 130/80 mmHg were
given omega-3 polyunsaturated fatty acids (PUFA) in the form of an
Omaco~
capsule 4 g/day equi-
valent to eicosapentaenoic acid (EPA) 1.88 g and docosahexaenoic acid (DHA) 1.48 g for 6 months. A
3 to 6 month follow-up was planned, with monthly evaluations of the patients.
By six months, the serum triglyceride was significantly reduced ( 143.45
เธ‘
62.65
vs
91
เธ‘
42.89
mg/dl, p
=
0.002), serum cholesterol was also reduced but not statistically significant (234.16
เธ‘
56.29
vs
219.76
เธ‘
51.25 mg/dl, p
=
0.07). There was a trend of increased serum high density lipoprotein (HDL)-
cholesterol (39.26 เธ‘ 10.56
vs
42.72 เธ‘ 8.37 mg/dl, p
=
0.056). Urine beta-2เธ—microglobulin was elevated
in IgA patients and decreased statistically significant after 3 months (453 เธ‘ 580
vs
308 เธ‘ 274 )lg/24 h,
p
<
0.001) and 6 months offish oil therapy (453
เธ‘
580
vs
142
เธ‘
182, p
<
0.03) while urine N-acetyl-
glucosaminidase (NAG) was of no significant difference both before and after fish oil administration
(21 เธ‘ 10
vs
22 เธ‘ 10 and 21 เธ‘ 9 U/24 h, p
=
0.08). Plasma malondialdehyde (MDA), the end product of
oxidative stress was statistically, significantly decreased (1.09
เธ‘
0.51
vs
0.89
เธ‘
0.49 nmol/L, p
=
0.003).
The study did not show any change in blood pressure, proteinuria, or serum creatinine.
The authors conclude from the results of this study that patients with idiopathic lgA nephro-
pathy with proteinuria and mildly reduced GFR did not benefit from short-term treatment with 4 g per
144
U. PARINYASIRI et al.
J Med Assoc Tbai
February 2004
day of omega-3 PUFA regarding the total protein excretion and glomerular filtration rate (GFR), but
the advantage was the improvement in tubular dysfunction, lipid profiles, and oxidative stress.
Key word : Fish Oil, Oxidative Stress, lgA Nephropathy
SOMPONG ONG-AJYOOTH, MS***,
SURIN KANYOG, MS***
The omega-3 polyunsaturated fatty acids in fish oil have been shown to produce beneficial
effects, such as a reduction in blood pressure, proteinuria, lipid levels and inflammation. Aggregated
immunoglobulin A obtained from lgA nephropathy patients induced greater oxygen free radicals in
polymorphonuclear leukocytes than other glomerulopathy. All of which may affect the course of lgA
nephropathy.
Twenty-three adult patients with biopsy proven lgA nephropathy, with proteinuria more than
I g/day, serum creatinine less than 3 mg/dl and blood pressure control less than 130/80 mmHg were
given omega-3 polyunsaturated fatty acids (PUFA) in the form of an
Omaco~
capsule 4 g/day equi-
valent to eicosapentaenoic acid (EPA) 1.88 g and docosahexaenoic acid (DHA) 1.48 g for 6 months. A
3 to 6 month follow-up was planned, with monthly evaluations of the patients.
By six months, the serum triglyceride was significantly reduced ( 143.45
เธ‘
62.65
vs
91
เธ‘
42.89
mg/dl, p
=
0.002), serum cholesterol was also reduced but not statistically significant (234.16
เธ‘
56.29
vs
219.76
เธ‘
51.25 mg/dl, p
=
0.07). There was a trend of increased serum high density lipoprotein (HDL)-
cholesterol (39.26 เธ‘ 10.56
vs
42.72 เธ‘ 8.37 mg/dl, p
=
0.056). Urine beta-2เธ—microglobulin was elevated
in IgA patients and decreased statistically significant after 3 months (453 เธ‘ 580
vs
308 เธ‘ 274 )lg/24 h,
p
<
0.001) and 6 months offish oil therapy (453
เธ‘
580
vs
142
เธ‘
182, p
<
0.03) while urine N-acetyl-
glucosaminidase (NAG) was of no significant difference both before and after fish oil administration
(21 เธ‘ 10
vs
22 เธ‘ 10 and 21 เธ‘ 9 U/24 h, p
=
0.08). Plasma malondialdehyde (MDA), the end product of
oxidative stress was statistically, significantly decreased (1.09
เธ‘
0.51
vs
0.89
เธ‘
0.49 nmol/L, p
=
0.003).
The study did not show any change in blood pressure, proteinuria, or serum creatinine.
The authors conclude from the results of this study that patients with idiopathic lgA nephro-
pathy with proteinuria and mildly reduced GFR did not benefit from short-term treatment with 4 g per
144
U. PARINYASIRI et al.
J Med Assoc Tbai
February 2004
day of omega-3 PUFA regarding the total protein excretion and glomerular filtration rate (GFR), but
the advantage was the improvement in tubular dysfunction, lipid profiles, and oxidative stress.
Key word : Fish Oil, Oxidative Stress, lgA Nephropathy
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