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Original ArticleOpen Access
Comparison of Topical Lomefloxacin 0.3 Per Cent versus Topical Ciprofloxacin 0.3 Per Cent for the Treatment of Presumed Bacterial Corneal Ulcers
PANIDA KOSRIRUKVONGS, MD*,
SABONG SRIVANNABOON, MD*,
Purpose : To compare the efficacy and safety of topicallomefloxacin 0.3 per cent with topical
ciprofloxacin 0.3 per cent for treating mildly severe suspected bacterial corneal ulcers.
Method : This prospective, randomized, double-masked controlled clinical trial was con-
ducted on 41 patients (41 eyes) with suspected bacterial corneal ulcers who were randomized into 2
groups: 23 patients were in the lomefloxacin group and 18 patients in the ciprofloxacin group. All of
these corneal ulcers were scraped for gram's stain, KOH preparation and microbiologic cultures before
starting treatment. The clinical success rate, the time to cure, the rates of treatment failures, ocular
signs and symptoms and the adverse effects of the study medication were evaluated.
Results : Topicallomefloxacin is equivalent clinically and statistically to topical ciprofloxacin.
No statistically significant treatment differences were found between lomefloxacin (100%) and cipro-
floxacin (100%) in terms of success rate. Similarly, no differences were noted in the time to cure (p
>
0.05), the treatment failure, or the resolution of the clinical signs and symptoms (p
>
0.05). The adverse
effects of lomefloxacin were superficial punctate keratitis (26.1%) and irritation (8.7% ), whereas those
of ciprofloxacin were superficial punctate keratitis (22.2% ), white precipitate (11.1%) and irritation
(11.1 %). However, no statistically significant differences of these adverse effects were found between
the two groups (p
>
0.05).
Conclusion : Lomefloxacin ophthalmic solution (0.3%) is equivalent clinically and statisti-
cally to ciprofloxacin ophthalmic solution (0.3%) for the treatment of mildly severe presumed bacterial
corneal ulcers without statistically significant differences in the adverse effects and discomfort.
Key word : Corneal Ulcer, Bacterial Keratitis, Lomefloxacin, Ciprofloxacin
SABONG SRIVANNABOON, MD*,
Purpose : To compare the efficacy and safety of topicallomefloxacin 0.3 per cent with topical
ciprofloxacin 0.3 per cent for treating mildly severe suspected bacterial corneal ulcers.
Method : This prospective, randomized, double-masked controlled clinical trial was con-
ducted on 41 patients (41 eyes) with suspected bacterial corneal ulcers who were randomized into 2
groups: 23 patients were in the lomefloxacin group and 18 patients in the ciprofloxacin group. All of
these corneal ulcers were scraped for gram's stain, KOH preparation and microbiologic cultures before
starting treatment. The clinical success rate, the time to cure, the rates of treatment failures, ocular
signs and symptoms and the adverse effects of the study medication were evaluated.
Results : Topicallomefloxacin is equivalent clinically and statistically to topical ciprofloxacin.
No statistically significant treatment differences were found between lomefloxacin (100%) and cipro-
floxacin (100%) in terms of success rate. Similarly, no differences were noted in the time to cure (p
>
0.05), the treatment failure, or the resolution of the clinical signs and symptoms (p
>
0.05). The adverse
effects of lomefloxacin were superficial punctate keratitis (26.1%) and irritation (8.7% ), whereas those
of ciprofloxacin were superficial punctate keratitis (22.2% ), white precipitate (11.1%) and irritation
(11.1 %). However, no statistically significant differences of these adverse effects were found between
the two groups (p
>
0.05).
Conclusion : Lomefloxacin ophthalmic solution (0.3%) is equivalent clinically and statisti-
cally to ciprofloxacin ophthalmic solution (0.3%) for the treatment of mildly severe presumed bacterial
corneal ulcers without statistically significant differences in the adverse effects and discomfort.
Key word : Corneal Ulcer, Bacterial Keratitis, Lomefloxacin, Ciprofloxacin
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