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Original ArticleOpen Access
Prospective Study of Hypotension after Spinal Anesthesia for Cesarean Section at Siriraj Hospital: Incidence and Risk Factors, Part 2
Ohpasanon P 
,
Chinachoti T ,
Sriswasdi P ,
Srichu S
,
Chinachoti T ,
Sriswasdi P ,
Srichu S Background: The incidence of hypotension after spinal anesthesia is highest in cesarean section. The authors’
first retrospective study identified three risk factors that included two non-modifiable (patient’s height and
low baseline systolic blood pressure) and one modifiable risk factor (sensory analgesia equal to or higher
than T5) associated with hypotension.
Objective: To create a prospective record of the event in the patients who received successful spinal anesthesia
for cesarean section.
Material and Method: A prospective data collection, together with questionnaires that were completed by the
responsible anesthetic team at the end of the operation for each consecutive patient. All parameters were
coded and recorded in SPSS11.5. To assess the association between two categorical variables in a univariable
analysis, chi-square test was used along with odds ratio (OR) and its 95% confidence interval (CI). Mutivariable
analysis via multiple logistic regressions was employed to determine the effect of each independent variable.
Results: Eight hundred and seven full term pregnant women received successful spinal anesthesia for cesarean
section at Siriraj Hospital from July 1 to December 31, 2004. Hypotension was defined as lowest systolic < 100
mmHg and the pressure was lower to equal to or more than 20% of baseline. Incidence of hypotension was
65.1%. Age > 35 yr, BMI > 35 were two non-modifiable risk factors that increased the incidence of hypotension
in the crude odds ratio (OR) 1.62 and 2.83 respectively with narrow 95% confidence interval. The level of
sensory analgesia equal to or higher than T5 was the only one modifiable risk factor that increased the
incidence of hypotension with crude OR 1.55 and narrow 95% CI.
Conclusion: Limitation of the dose of local anesthetic agent or addition of some opioids could reduce the
incidence and severity of hypotension after spinal anesthesia for cesarean section.
Keywords: Hypotension, Spinal anesthesia, Cesarean section
first retrospective study identified three risk factors that included two non-modifiable (patient’s height and
low baseline systolic blood pressure) and one modifiable risk factor (sensory analgesia equal to or higher
than T5) associated with hypotension.
Objective: To create a prospective record of the event in the patients who received successful spinal anesthesia
for cesarean section.
Material and Method: A prospective data collection, together with questionnaires that were completed by the
responsible anesthetic team at the end of the operation for each consecutive patient. All parameters were
coded and recorded in SPSS11.5. To assess the association between two categorical variables in a univariable
analysis, chi-square test was used along with odds ratio (OR) and its 95% confidence interval (CI). Mutivariable
analysis via multiple logistic regressions was employed to determine the effect of each independent variable.
Results: Eight hundred and seven full term pregnant women received successful spinal anesthesia for cesarean
section at Siriraj Hospital from July 1 to December 31, 2004. Hypotension was defined as lowest systolic < 100
mmHg and the pressure was lower to equal to or more than 20% of baseline. Incidence of hypotension was
65.1%. Age > 35 yr, BMI > 35 were two non-modifiable risk factors that increased the incidence of hypotension
in the crude odds ratio (OR) 1.62 and 2.83 respectively with narrow 95% confidence interval. The level of
sensory analgesia equal to or higher than T5 was the only one modifiable risk factor that increased the
incidence of hypotension with crude OR 1.55 and narrow 95% CI.
Conclusion: Limitation of the dose of local anesthetic agent or addition of some opioids could reduce the
incidence and severity of hypotension after spinal anesthesia for cesarean section.
Keywords: Hypotension, Spinal anesthesia, Cesarean section
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