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The Factors Associated with Mild Cognitive Impairment (MCI) in Surgical Menopause Women

Kengsakul M , Chaikittisilpa S , Hemrungrojn S , Panyakhamlerd, K , Jaisamrarn U , Taechakraichana N

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Kengsakul M, Chaikittisilpa S, Hemrungrojn S, Panyakhamlerd, K, Jaisamrarn U, Taechakraichana N. The Factors Associated with Mild Cognitive Impairment (MCI) in Surgical Menopause Women. J Med Assoc Thai 2015;98:327.

Background and Objective: As a sizeable proportion of persons with mild cognitive impairment will progress to frank dementia, early detection is an important strategy to prevent and decelerate the progression of cognitive decline. In Thailand, the prevalence of mild cognitive impairment in surgical menopause women has not been well established. The objectives of the present study were to determine the percentage and factors associated with mild cognitive impairment in women with surgical menopause.

Material and Method: Between October 2013 and July 2014, 200 eligible women at King Chulalongkorn Memorial Hospital were enrolled. The self-reported questionnaires were used to obtain the demographic data and the Thai version of the Montreal Cognitive Assessment (MoCA) was used to detect mild cognitive impairment (MCI). The MCI was diagnosed when the MoCA score was less than 25. The data were statistically analyzed using SPSS version 17 for student t-test, Chisquare test, and multiple regression analysis.

Results: The percentage of MCI in the present study was 43.5%. The univariate analysis showed that factors significantly related to MCI were marital status, educational levels, occupation, monthly income, and duration of hormone replacement therapy (HRT). Nevertheless, multiple regression analysis revealed that only older age at enrollment, marital status, low educational level, and low monthly income were significantly related to MCI.

Conclusion: Almost half of the surgical menopause women in the present study had MCI. Older age at enrollment, marital status, low educational level, and low monthly income were significantly related to MCI. Age at surgical menopause and HRT were not found to be associated with MCI in this study.

Keywords: Mild cognitive impairment (MCI), Surgical menopause

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