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Original ArticleOpen Access
Comparative Study of Direct - Measured and Calculated LDL in Clinical Use
Rungtanapirom S 
,
Ongphiphadhanakul B ,
Kiatbamrungpunt T ,
Bhakdikul J ,
Archavanuntakun S ,
Taerakul C ,
Pongsanguansin J ,
Charoenloet V ,
Tansanguan K
,
Ongphiphadhanakul B ,
Kiatbamrungpunt T ,
Bhakdikul J ,
Archavanuntakun S ,
Taerakul C ,
Pongsanguansin J ,
Charoenloet V ,
Tansanguan K Objective: Compare DLDL-C and CLDL-C obtained during regular service in hospital.
Material and Method: The study at Bangkok Hospital included 9,285 lipid profiles of different individuals
that contained total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), and directly-measured (by
homogeneous method) LDL cholesterol (DLDL-C). The population has mean age 45.92 + 12.43 years, 48%
were male. LDL-C values were also calculated by Friedewald equation (CLDL-C). However, it was known to
have limitation when TG > 400 mg/dL.
Results: The DLDL-C is 13.4 + 8.8% higher than CLDL-C. The authors could obtain CLDL-C closer to DLDL-C
in wider TG range, including other explanatory variables in the equation to calculate LDL-C, by these two
equations, DLDL-C = 0.98 TC – 0.84 HDL – 0.12 TG + 0.056 age + 0.071 BMI, and DLDL-C = 0.98 (TC – HDL)
– 0.12 TG + 0.1 age + 2.4 sex + 0.2 BMI.
Conclusion: DM and using lipid-lowering medications had no effect on the correlation of CLCL-C and
DLDL-C.
Keywords: Friedewald equation, LDL measurement, LDL, LDL equation
Material and Method: The study at Bangkok Hospital included 9,285 lipid profiles of different individuals
that contained total cholesterol (TC), triglyceride (TG), HDL cholesterol (HDL-C), and directly-measured (by
homogeneous method) LDL cholesterol (DLDL-C). The population has mean age 45.92 + 12.43 years, 48%
were male. LDL-C values were also calculated by Friedewald equation (CLDL-C). However, it was known to
have limitation when TG > 400 mg/dL.
Results: The DLDL-C is 13.4 + 8.8% higher than CLDL-C. The authors could obtain CLDL-C closer to DLDL-C
in wider TG range, including other explanatory variables in the equation to calculate LDL-C, by these two
equations, DLDL-C = 0.98 TC – 0.84 HDL – 0.12 TG + 0.056 age + 0.071 BMI, and DLDL-C = 0.98 (TC – HDL)
– 0.12 TG + 0.1 age + 2.4 sex + 0.2 BMI.
Conclusion: DM and using lipid-lowering medications had no effect on the correlation of CLCL-C and
DLDL-C.
Keywords: Friedewald equation, LDL measurement, LDL, LDL equation
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