Background: Although there is no standard treatment of eyebrow hypotrichosis, many physicians have been prescribing minoxidil lotion. We demonstrated in the previous study that 2% minoxidil lotion was a safe and effective treatment for eyebrow hypotrichosis.

Objective: The aim of the present study is to determine the efficacy and safety of 1% minoxidil lotion compared to placebo for eyebrow enhancement.

Material and Method: A total of 42 subjects (18-60 years old) were randomized to apply 1% minoxidil on one side of eyebrow and placebo on the other side. Efficacy and side effects were evaluated every 4 weeks for 16 weeks.

Results: Forty subjects (95%) completed this 16-week study. At week 16, 1% minoxidil was significantly superior to placebo for global photographic assessment, eyebrow diameter, eyebrow hair count, and patient’s satisfaction. There was no difference in side effects between two groups.

Conclusion: Our study showed that 1% minoxidil was a well-tolerated and effective treatment for eyebrow hypotrichosis

Keywords: eyebrow, hypotrichosis, minoxidil, placebos, therapy