Background: The pharmacological properties of Allium ascalonicum Linn., commonly called shallot, have been reported as including those that are antibacterial and antioxidant.
Objective: The present study aimed to evaluate the antimicrobial effect and wound-healing activity of the ethanolic extracts of Allium ascalonicum Linn. (AAE).
Material and Method: The antimicrobial activity of AAE was tested in vitro against using the disc diffusion method and a broth micro-dilution technique to determine the minimal inhibition concentrations (MIC) and the minimal microbicidal concentrations (MMC). Wound-healing activity of the extract was performed on rat test subjects.
Results: The AAE showed potential antimicrobial activity by inhibiting gram-positive bacteria Staphylococcus epidermidis
and Bacillus subtilis ATCC 6633. MIC and MMC varied from 25-50 mg/ml and 25-200 mg/ml, respectively. After surgery 14 days, wound contractions of treated groups and standard group were 78.61+1.20%, 78.55+1.93% and 100%, respectively; but, in the control group, wound contraction was 64.90+3.55%. Histological studies showed the complete epidermis and found the collagen fibers and fibroblasts as similar appearance as standard group in dermis. The results of histological evaluation have confirmed remarkable wound-healing activities of AAE.
Conclusion: Taken together, the present study provides evidence that AAE extract processes antimicrobial and woundhealing activities.

Keywords: Allium ascalonicum Linn., Antimicrobial activity, Wound-healing