Neurological involvement in Henoch-Schönlein purpura (HSP) such as stroke is uncommon
manifestiation, particularly in association with Staphylococcus aureus (S. aureus). The authors reported a
17-year-old man who developed sudden onset of right hemiparesis while he was admitted in the hospital
about his prolonged fever, palpable purpura and upper gastrointestinal bleeding. He also had evidence of
MRSA septicemia before the onset of right hemiparesis. Skin biopsy was done and showed that there was
leukocytoclastic vasculitis with IgA deposition. He had received completed course of antibiotics and then he
was subsequently improved after steroid therapy in the next 2 weeks. Review of case reports from previous
English literatures, discovered the association between MRSA infection and HSP which can cause several
CNS manifestations including stroke symptoms from cerebral vasculitis.

Keywords: Stroke, Henoch-Schönlein purpura, Cerebral vasculitis, MRSA septicemia