The purpose of this study is to identify the lowest value of NMID osteocalcin and PINP when CTx is below or equal to 0.10 ng/ml at which neither bone formation nor bone resorption occurs. This may be harmful to bone texture. The 223 cases of CTx equal or below 0.100 ng/ml of CTx were enrolled. They consisted of 42 cases or 18.83% of menopausal women, 110 cases or 49.32% of post anti-resorptive therapy, 22 cases or 9.8% elderly and 49 cases or 21.97% unknown causes. The results show PINP = 15.88 ng/ml and NMID osteocalcin = 10.81 ng/ml. We used them as a cut value for diagnosis of bone condition.
The benefits of this study: helping the physician in the treatment of bone diseases, osteoporosis in cases of over treatment; when the value of CTx is below or above 0.1 ng/ml or 0.01-0.099 ng/ml; when there is no bone resorption and osteoblastic function is poor if the values of NMID osteocalcin or PINP are still equal to 10.81, 15.88 ng/ml at any level of BetacrossLap, respectively.

Keywords: Bone marker, NMID osteocalcin, PINP, CTx, Betacrosslap, Cut value, Osteoblastic function