Disseminated intravascular coagulation (DIC) is a syndrome characterized by systemic activation of blood coagulation, generation of thrombin, and leading to disturbance of the microvasculature. In this article, definition and diagnostic criteria of DIC depend on the International Society of Thrombosis and Haemostasis (ISTH). There is no gold
standard for diagnosis of DIC, only low quality evidence is used in general practice. Many diagnostic tests and repeated
measurement are required. For the treatment of DIC, there is no good quality evidence. The most important treatment for DIC
is the specific treatment of the conditions associated DIC. Platelets and/or plasma transfusion may be also necessary if
indicated. Nevertheless, there is no gold standard for diagnosis and treatment of DIC, we use only low quality evidence in general practice.

Keywords: Disseminated intravascular coagulation, Blood coagulation, Coagulation factors, Thrombosis