Background: Pain after major craniotomy has been believed to be less severe than the other operations.
Objective: To determine the incidence and risk factors of moderate to severe pain after major craniotomy.
Material and Method: This is a prospective observational study in a neurosurgical intensive care unit and wards of a
university, tertiary hospital. After institutional IRB approval, patients undergoing major craniotomy during May 2011-August
2012 were interviewed preoperatively and 24 and 48 hours postoperatively. Demographic data, preoperative anxiety scores, operative data and postoperative pain characteristics were recorded.
Results: Two hundred and eighty patients completed the study. The incidence of moderate to severe pain was 75%. Mean pain
score during 24 and 48 hours were 5.5+2.7 and 3.5+2.6, respectively. Univariate analysis identified age under 45 years and perioperative steroid therapy as predictors of moderate to severe postoperative pain. Using multivariate analysis, only age
under 45 years was a significant risk factor. Patients’ satisfaction scores were good in both mild and moderate to severe pain groups (9.49+1.08 and 8.37+1.76). During postoperative period, almost all of the patients received intravenous opioid and oral acetaminophen for pain treatment. No respiratory depression occurred, but postoperative nausea and vomiting occurred in 51.7% and pruritus in 23.6%.
Conclusion: Incidence of pain after craniotomy was high especially in younger age group, which is not in accordance with
all similar reports. However, we believe pain management after major craniotomy in our hospital requires improvement.

Keywords: Postoperative pain, Craniotomy, Incidence, Risk factors