Two Thai women who are siblings presented with a history of recurrent pruritic vesicles on dorsum of
both hands and extensor surface of forearms where the sun-exposed areas are. The excoriated vesicles were
healed with depressed scars. They had no previous history of intense abdominal pain, seizure, or psychiatric
disorder. Urinary porphyrins were analyzed by High Performance Liquid Chromatography (HPLC). The level
of coproporphyrin III was detected to be higher than the uroporphyrin level. Fluorescence emission scanning
of both patients’ plasma was performed and demonstrated typical emission peak at 626 nm, that confirmed the
diagnosis of variegate porphyria.

Keywords: Variegate porphyria, Plasma Fluorescence emission scanning, Thai