Background: Radiation therapy is generally accepted treatment of choices for many benign and malignant tumors. A potential
late sequela is the development of secondary malignancies around the treated zone.
Objective: To report a case of rapid development of a secondary cutaneous squamous cell carcinoma, as a potential adverse sequence of post-radiation therapy.
Material and Method: A case report and a literature review are provided.
Results: A middle aged woman with locally advanced breast cancer of her left breast developed a secondary squamous cell
carcinoma at two years after radiotherapy.
Conclusion: A post-radiation cutaneous carcinomas is an uncommon complication of radiation therapy. Diagnosis of the
secondary malignancy is often delayed because of its similarities with post-radiation skin lesion or the recurrence of the original tumors.

Keywords: Secondary malignancy, Post-operative radiation, Squamous cell carcinoma, Breast cancer