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Objective: To investigate if oral sucrose solution decreased pain and physiological distress during ROP examination.
Material and Method: Infants <32 weeks gestation or birth weight <1,500 g or selected infants birth weight between 1,500 and 2,000 g or gestational age more than 32 weeks and infants at risk were enrolled. The intervention group received one dose of 0.2 ml of 24% oral sucrose solution compared to control group who received sterile water as a placebo 2 minutes prior to the first ROP examination. Pain was evaluated using a Neonatal Pain, Agitation and Sedation Scale (N-PASS) before and during eye examination.
Results: Forty infants were randomized into 2 groups (19 infants in intervention group and 21 infants in control group). N-PASS was found to be significantly lower in intervention group (2 points difference; p = 0.02). Eleven infants (57.9%) in intervention and 14 infants (66.7%) in control group had tachycardia with significant increased heart rate from baseline. No serious adverse event was observed in both groups.
Conclusion: Single dose of 24% oral sucrose solution is effective in pain reduction during ROP examination.
Keywords: oral sucrose solution, N-PASS (Neonatal Pain, Agitation and Sedation Scale), retinopathy of prematurity (ROP)