J Med Assoc Thai 2017; 100 (6):679

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Original ArticleOpen Access
Haplotype Analysis of Genetic Polymorphism in Antisocial Alcoholism
Kongsakon R , Sathirapongsasuti N , Rerkamnuaychoke B Mail

Background: A number of studies have reported a possible association between Monoamine oxidase A (MAOA) polymorphisms and alcoholism. MAOA dysfunction appears to be related to a subtype of alcoholism with antisocial impulsive features (type 2: antisocial alcoholism). Functional polymorphisms in the MAOA gene are believed to be good candidates to consider in the inter-individual differences that exist in the susceptibility to alcoholism and/or antisocial personality.

Objective: To examine the association between alcoholism and the allele state of 1) 30-bp repeat polymorphism in the promoter region, 2) 941T > G polymorphism in exon 8, and 3) 1460C > T polymorphism in exon 14 of the MAOA gene.

Material and Method: Genomic DNA was extracted from venous blood samples of 251 alcoholic subjects and 77 healthy controls. The alcoholic subjects were divided into two groups, type 1 (n = 125) and type 2 (n = 126). All of the subjects were unrelated males of Thai, Thai/Chinese, or Chinese descent.

Results: There was no significant difference in the allele frequencies or haplotype distribution between type 1, type 2 antisocial alcoholism, and healthy controls.

Conclusion: We are still unable to conclude the association between genetic variation of MAOA locus and antisocial alcoholism in Thai males according to under prevalent condition of the sample size and allele frequency.

Keywords: Antisocial alcoholism, MAOA genotyping, Polymorphisms, Alleles, Haplotypes


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