J Med Assoc Thai 2017; 100 (4):150

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Outcomes of Porcine Acellular Dermal Matrix in Patients with Extensive Burn Scars
Muangman P Mail, Wetwittayanugoon C , Chinaroonchai K , Somcharit L , Sirikun J , Chunhasuwankul R

Background: Scar excision and wound coverage with skin graft is one of the standard techniques for treatment of burn scar
contracture. However, patients with extensive burn scars might have limited donor areas for split thickness skin grafts. In the
past 20 years, there have been many clinical innovations over the use of dermal regeneration template. But there were limited
clinical studies of porcine acellular dermal matrix, especially in extensive burn scars.
Objective: This study was design to evaluate the outcomes of porcine acellular dermal matrix in patients with extensive burn
Material and Method: Patients with more than 40% burn area that were admitted and received debridement and coverage with Pelnac® dermal substitute since January to December 2012 were enrolled in this study.
Results: 8 extensive burns (9 burn areas) with a mean age of 25.5+10.26 years underwent debridement and coverage with
Pelnac® dermal substitute. 4 patients (44.4%) were male and 4 patients (44.4%) were female. The mean burn percentage was
64.6+16.59% (range, 40 to 92%). The Vancouver scar scales at 3, 6 and 12 months of 8 patients and 9 burn areas had significant improvement after treatment (p-value <0.05). There was no infectious complication in this study.
Conclusion: The porcine acellular dermal matrix demonstrated the effective treatment outcomes in extensive burn patients with limited area of donor sites for skin graft.

Keywords: Porcine, Acellular dermal matrix, Post-burn scar, Scar treatment, Extensive burns

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