XML | Respond to this article | Alert & updates | Request permissions | Email to a friend |
Objective: To study the prevalence of HR-HPV, high grade cervical intraepithelial neoplasia (CIN2/3) and cancer diagnosis in women who had liquid-based cervical cytology (LBP) report with low grade and high grade squamous intraepithelial lesion (LSIL and HSIL) in the women who attended gynecological clinic for cervical cancer screening.
Material and Method: This retrospective study recruited participants who underwent co-testing (LBP with HPV testing) between July 2013 and June 2016 from medical records. Participants with abnormal Pap smear i.e., LSIL, HSIL, and malignancy were included. Data collected including age, Pap reports and HPV testing results. Cervical cytology, histopathological report from colposcopic directed biopsy and HR-HPV testing were analyzed.
Results: A total of 2,144 participants were enrolled. Prevalence of LSIL, HSIL and cancer from LBP were 1.4% (30), 1.07% (23) and 0.37% (8), respectively. CIN2+ in cases with LSIL and HSIL reports were 7.1% and 8.6%, respectively. There was no cancer in women who had LBP report of LSIL. In this study, there was no case of CIN2/3 in women with LSIL who had HR-HPV negative (negative predictive value; NPV 100%). All of women with HSIL reports had HR-HPV testing positive. Ninety percent of cases with HSIL reports had histopathological reports CIN2/3 and cancer.
Conclusion: In women with LSIL reports and negative HR-HPV testing, there was no silent CIN2/3. In the situation that colposcopy was not available, HR-HPV testing and LBP can assist the medical person to reduce the colposcopy referral.
Keywords: Cervical intraepithelial neoplasia, Cancer, Colposcopy, Pap, HPV testing