Background: Thunbergia laurifolia Lindl. belongs to the family Acanthaceae commonly known as Rang jeud in Thailand. This plant is traditionally used in Thailand for centuries as an antidote for several poisons and drug overdose.
Objective: This research aimed to study the anti-inflammatory, analgesic and antipyretic activities of T. laurifolia water extract by using animal models.
Material and Method: The anti-inflammatory study was conducted by 3 experiments in animal models namely ethyl phenylpropiolate (EPP)-induced ear edema, carrageenan or arachidonic acid-induced paw edema and cotton pellet-induced granuloma formation. The analgesic activity was studies using 2 methods of pain induction including acetic acid and heat induced pain. Finally, the antipyretic activity study was performed by yeast-induced hyperthermia.
Results: The results showed that the administration of T. laurifolia extract possessed acute anti-inflammatory effects in EPPinduced ear edema and carrageenan or arachidonic acid-induced paw edema. The extract showed the analgesic activity by reducing acetic acid-induced writhing response and heat-induced pain as well as showed antipyretic activity by decreasing body temperature of hyperthermic rats induced by brewer’s yeast.
Conclusion: The study indicates that the T. laurifolia extract possesses the anti-inflammatory, analgesic and antipyretic activities in animals.

Keywords: Thunbergia laurifolia extract, Anti-inflammatory activity, Analgesic activity, Antipyretic activity