Objective: To investigate dyslipidemia effects on HRV and HRV correlations with plasma lipids and adiposity measures in Thai overweight dyslipidemic individuals.

Material and Method: HRV of 84 dyslipidemic subjects (age 48.7±6.7 years, BMI 25±2.3 kg/m2) were compared with 20 normolipidemic subjects (56±2.3 years, BMI 26±1.7 kg/m2). Then, HRV correlations with lipid levels and adiposity were assessed in 84 dyslipidemic subjects. HRV was determined from 10-minute continuous resting electrocardiography. Anthropometry, body composition, and plasma lipid profile, measured in blood samples after overnight fasting, were also measured.

Results: Total power (p<0.01), low-frequency power (LF) (p<0.01), high-frequency power (HF) (p<0.01), LF/HF ratio (p<0.05), standard deviation of R-R interval (p<0.01), square root of the mean squared difference between adjacent normal R-R intervals (p<0.01), and percentage difference between adjacent normal R-R intervals greater than 50 ms (p<0.01) were significantly lower in dyslipidemic than normolipidemic subjects. HF (nu) in these dyslipidemic subjects negatively correlated with triglycerides (TG), TG/high-density lipoprotein cholesterol (HDL-c) ratio, and waist-to-hip (W/H) ratio whereas, LF (nu) and LF/HF ratio positively correlated with TG, TG/HDL-c ratio, and W/H ratio.

Conclusion: Autonomic imbalance correlated with CVD risk factors in Thai overweight dyslipidemic individuals, suggesting increased CVD risk.

Keywords: Lipid profile, Autonomic imbalance, Cardiovascular disease risk