Hepatic hemangioma is one of the most common benign liver tumors. Hemangiomas can occur in people of all ages but are more commonly found in young women. Most patients have only one hemangioma, but multiple lesions are possible. The natural history of hemangiomas is usually benign, and bleeding or rupture is very rare. The treatment for bleeding or ruptured hemangioma includes embolization or surgery. The authors reported a case of a young female with giant bilateral hepatic hemangioma with bleeding. The size of the hemangioma precluded resection or enucleation. Transarterial embolization of her hepatic arteries was done but failed. She received orthotopic liver transplantation and had an uneventful post-operative course. Currently, she is doing well. This report is the first case in Thailand of liver transplantation as the rescue therapy for a patient with bleeding giant hepatic hemangioma.

Keywords: Giant hepatic hemangioma, Liver transplantation, Bleeding