J Med Assoc Thai 2019; 102 (2):214-21

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A 5-Year Experience with Medulloblastoma at Queen Sirikit National Institute of Child Health: Case Series
Tadadontip P Mail

Objective: To review management and outcome of treatment of medulloblastoma patients over a 5-year period, between 2010 and 2014, at Queen Sirikit National Institute of Child Health (QSNICH).

Materials and Methods: A retrospective case series of medulloblastoma patients treated at QSNICH by the author between 2010 and 2014 was conducted. Demographic data of patients including sex, age at diagnosis, clinical risk stratification, histopathological subtype of medulloblastoma, mode of treatment, complication, and result of treatment were reviewed and discussed.

Results: During the 5-year period, 11 medulloblastoma patients were treated by the author at QSNICH. Six of them were male. Three patients were less than 3-year-old at diagnosis. Five patients were classified as standard risk and six patients were highrisk. Histopathological subtype of medulloblastoma were classic in nine cases, desmoplastic subtype in one case and another case was medulloblastoma with extensive nodularity (MBEN). All patients were operated. Tumor were totally removed in nine cases, confirmed by postoperative magnetic resonance imaging (MRI). After surgery, two cases were referred, and eight cases received adjuvant therapies including radiotherapy and chemotherapy. One case was treated palliatively. Eight patients were able to be followed after treatment. Three patients expired, two of them expired from diseases progression and one expired from complications of treatment. In 2017, three patients lived longer than five years after diagnosis.

Conclusion: Treatment of medulloblastoma at QSNICH has improved during recent years. Morbidity and Mortality of medulloblastoma patients were not only cause by disease itself but also by complication of treatment too. Retrospective review of treatment protocol and outcome of the author’s institute are crucial to improve the results of treatment. However, longer followed-up period and more cases are required to be included in future studies.

Keywords: Medulloblastoma, Histopathological subtype, Clinical risk stratification

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