Materials and Methods: The study design was randomized, double-blind, placebo-controlled trial. Informed consents were obtained. Baseline characteristics were recorded. One hundred thirty women participated in the present research, 65 subjects were placed into each group equally by simple computerized randomization. IUD was inserted, pain score was evaluated, and the analysis was performed. There was no dropout.

Results: More than 50% of subjects experienced significant pain immediately after IUD insertion. Etoricoxib 120 mg before the procedure did not significantly reduce the pain. Etoricoxib seems to be effective among women who never had vaginal delivery. The median pain score was 7 in the placebo group and 5 in the Etoricoxib group. Ninety-two-point-nine percent of the participant in the placebo group had significant pain compared to 66.7% in the Etoricoxib group.

Conclusion: Etoricoxib 120 mg does not help in relieving pain as preemptive analgesia for IUD insertion. However, it seems to be more effective for women who never experienced vaginal delivery.

Keywords: Etoricoxib, IUD insertion, Pain scores, Preemptive analgesia