J Med Assoc Thai 2017; 100 (10):13

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Original ArticleOpen Access
Effect of Thunbergia laurifolia Extract on Cerebral Blood Flow in Rats
Thongsaard W Mail, Jariyapongskul A , Areebambud C

Background: Thunbergia laurifolia Linn. (TL) is a herbal medicine which has been used as an antidote for several poisonous agents including insecticides and as a component of a mixture of crude extracts to treat drug addicted patients. The previous study using Functional Magnetic Resonance Imaging (fMRI) technique found that oxyhemoglobin: deoxyhemoglobin increased in amygdala, caudate and nucleus accumbens by TL. These areas represent reward and addiction behavior.

Objective: The present study aim to investigate the direct effect of TL (100, 200 and 300 mg/kg) on cerebral blood flow, mean arterial blood pressure, partial pressures of oxygen and carbondioxide in normal rats.

Material and Method: Methanol extract of TL (100, 200 and 300 mg/kg, n = 12 in all groups) was administered intraperitoneally to rats. Cerebral blood flow, mean arterial pressure, pH, PO2 and PCO2 were measured at 5 min before, 5, 10, 20 and 30 min after injection.

Results: The results showed a significant increase in cerebral blood flow and mean arterial blood pressure in a dose-related manner, but partial pressures of oxygen and carbondioxide were not affected.

Conclusion: The finding explains that TL cause the increase in oxyhemiglobin: deoxyhemoglobin by increasing cerebral blood flow and mean arterial blood pressure.

Keywords: Cerebral blood flow, Mean arterial blood pressure, Thunbergia laurifolia


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