Objective: To evaluate serum chloride level after loading dose of sterofundin solution given to healthy volunteers in the resuscitation manner compared with normal saline solution.

Materials and Methods: Ten healthy volunteers were randomly assigned to receive normal saline or sterofundin for the first solution in dose of 30 mL/kg (maximum 2 liters) over one hour. After washout period of at least one week, crossover studies were performed in the same participants with another remaining solution (10 participants for each solution, total n = 20). For each solution loading, blood was collected at baseline (T0), at 60 minutes (T1), 120 minutes (T2), and 240 minutes (T4) from baseline. Time to first void after initiation of fluid and urine volume were also recorded. Primary outcome was change in serum chloride level.

Results: With sterofundin loading, delta chloride level change from baseline at T1, T2, and T4 were 2.33±1.41, 0.78±0.83, and 0.89±1.17, respectively, which were significantly lower than delta change after normal saline loading (4.2±1.03, 3.3±1.16, and 2.4±1.58, p = 0.021). The decrease in SID was lesser (p = 0.017), time to first void was significantly shorter (p = 0.008), with larger but not statistically significant urine volume (p = 0.068).

Conclusion: Sterofundin solution loading slightly increased serum chloride level, but delta change from baseline was significantly lower as compared with normal saline solution.

Keywords: Chloride, Fluid, Normal saline, Osmolality, pH, Resuscitation, SID, Sterofundin, Urine