Background: Gastric cancer is the second leading cause of cancer death and the fourth most common cancer worldwide. For patients considered curable, surgery is the main curative treatment. There is controversy regarding extensiveness of lymph node dissection between D1, limited to the perigastric nodes, and D2, extended to regional lymph nodes outside the perigastric area.

Objective: The objective of the present study was to compare the survival rate of patients that underwent D1 and D2 gastrectomy at Srinagarind Hospital.

Materials and Methods: The present research was a retrospective cohort study. The inclusion criterion was all resectable gastric cancer patients that underwent gastrectomy with lymphadenectomy for curative intention at Srinagarind Hospital between January 2010 and December 2014. The primary outcome was the survival rate of patients with D1 and D2 gastrectomy.

Results: Seventy-four eligible patients were included. The overall 5-year and median survival time of all recruited patients in the present study were 17.4% (95% CI 5.9 to 28.9) and 584 days (95% CI 446 to 722) with comparable survival between D1 and D2 group. There were 10 cases (13.51%) of morbidity such as bile leakage, wound infection, pancreatic fistula, upper gastrointestinal bleeding, and re-operation from postoperative bleeding. There was one case (1.35%) of postoperative mortality. Postoperative complications and mortality of D1 and D2 group did not differ significantly (p=0.20).

Conclusion: No difference was found in the survival and complication between D1 and D2 gastrectomy at Srinagarind Hospital.

Keywords: Gastric cancer, D1 gastrectomy, D2 gastrectomy, Survival, Morbidity, Mortality