J Med Assoc Thai 2009; 92 (3):390

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Late Effects and Cosmetic Results of Simultaneous Integrated Boost Versus Sequential Boost after Conventional Irradiation in Breast-Conserving Therapy; Out Come of 7 Months Follow-Up
Raiyawa T Mail, Lertbutsayanukul C , Rojpornpradit P

Objective: To compare simultaneous integrated boost and sequential boost after conventional irradiation in
breast-conserving therapy in aspect of late effects and cosmetic results.

Material and Method: Between August 2006 and June 2007, 60 breasts were treated in this prospective nonrandomized
study, designed to compare simultaneous integrated boost (additional 10Gy/25F) and sequential
boost (15Gy/5F) to the tumor bed in terms of late effects and cosmetic results at 7-month and 3-year follow-up.
Pearson Chi-square test was used, with an α-value of 0.05.

Hyper/hypopigmentation and induration/fibrosis were commonly seen at 7-months follow-up (p =
0.84 and 0.83, respectively). The cosmetic results were good or excellent.

Conclusion: Although the present study included a small number of patients and short follow-up time, the
preliminary results were comparable between the study groups.

Keywords: Breast neoplasms, Radiation dosage, Radiotherapy dosage, Radiation, Radiation injuries

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