Melanoma is melanocytic tumour that can be primary or metastatic. Though the metastatic melanoma is the third most common of the central nervous system metastases, the metastatic intramedullary melanoma is rare and diagnostic challenges. Melanoma is the tumour that closely mimics other tumour due to variations including morphology, architecture, stromal component and immunohistotype which are similar to those found in other tumours. The diverse variants of melanoma result potential diagnostic pitfalls in histological assessment. The authors reported a case of intramedullary spinal cord metastatic melanoma, plasmacytoid variant which had a diagnostic challenge to the pathologist involved.

Keywords: Spine intramedullary tumour, Melanoma, Plasmacytoid variant