Objective: To study complications of surgery in patients with drug-resistant epilepsy whom underwent surgery at Prasat Neurological Institute.

Materials and Methods: Patients with drug resistant epilepsy whom underwent surgical treatment at Prasat Neurological Institute between 2011 and 2015 were retrospectively reviewed. Surgical and neurological complications were analyzed into transient and permanent complications. All patients had a minimum of one year follow-up.

Results: One hundred ninety-four epileptic patients were reviewed. There were 199 therapeutic operations and 21 diagnostic operations without operative mortalities. Thirty-one patients (15.6%) had surgical complications. The most common surgical complication was infection (70%). Fifteen patients (7.5%) had transient neurological complications and seven patients (3.5%) had permanent neurological complications. Dysphasia resulting from surgical resection in the dominant hemisphere was the most common cause of permanent neurological complication. Side and type of surgery were the predictor of complication after epilepsy surgery (p<0.05).

Conclusion: Complications of epilepsy surgery at Prasat neurological institute had comparable rate to other epilepsy centers. Epilepsy surgery is safe but carries some risks. The data are beneficial for preoperative counseling to the patients before the surgery.

Keywords: Complication, Epilepsy surgery, Epilepsy, Morbidity