The authors reported three Thai patients diagnosed with Cronkhite-Canada Syndrome [CCS]. All patients presented with chronic diarrhea resulting from gastrointestinal [GI] polyposis and the characteristic cutaneous findings, hyperpigmented skin, nail dystrophy, and/or hair loss. CCS is uncommon worldwide, with only one previously reported case from Thailand. To the authors knowledge, this was the first case series of Thai CCS patients. In the present report, the authors summarized the epidemiologic and clinical information of the Thai patients and compared them to the data from other countries. The frequency of each cutaneous finding and the histologic type of the polyps differed between Thai patients and other ethnic groups.

Keywords: Cronkhite-Canada syndrome, First case series, Thai population