Objective: To determine factors associated with childhood non-atopic asthma comparing to those with atopic asthma
Materials and Methods: A cross-sectional study was conducted among asthmatic pediatric patients aged between 1 month and 15 years of age who were treated between 2008 and 2013 at Department of Pediatrics, Charoenkrung Pracharak Hospital. Positive skin prick test with at least 1 allergen indicated atopic asthma whereas the negative test indictaed non-atopic asthma. Population characteristics and factors associated with non-atopic asthma were compared with atopic group.
Results: Of 373 childhood asthmatic patients studied, 189 (50.7%) had non-atopic asthma. Median age at onset and medain age of non-atopic asthmatic patients were significantly younger than atopic asthmatic patients: 1.16+1.29 years vs. 2.18+1.99 years (p<0.001) and 2.91+2.08 years vs. 5.45+3.33 years (p<0.001), respectively. Factors associated with a significantly greater risk of non-atopic comparing to atopic asthma included age at onset <1 year old, a history of wheezing associated with upper respiratory tract infection, and a history of breastfeeding >6 months.
Conclusion: Factors associated with a greater risk of non-atopic asthma were age at onset <1 year old, a history of wheezing associated with upper respiratory tract infection, and a history of breastfeeding >6 months.

Keywords: Non-atopic asthma, Risk factors