Ewing’s sarcoma [ES] is a rare cancer which usually presents in childhood or early adulthood. Most are found in osseous sites. Uterine cervix is an uncommon site for ES, with only 18 patients previously reported. Our patient was a 34 years old woman, who presented with abnormal vaginal bleeding. Pelvic examination showed an 8-cm mass prolapsed from cervix to vagina with purulent discharge in vagina canal. Uterus and adnexa were unremarkable. Pathology from biopsy showed only few tiny fragments of benign endometrial tissue admixed with blood component. Preoperative diagnosis was prolapsed submucous leiomyoma. Total hysterectomy was performed. Histologic features showed small blue round tumor cells with positive vimentin, neuron-specific enolase [NSE] and CD99 stains. Pancytokeratin and leukocyte common antigen [LCA] stains were negative. Fluorescence in situ hybridization [FISH] revealed ESWR1 gene rearrangement, establishing a diagnosis of Ewing’s sarcoma. Recurrent tumors were experienced 2 months after operation as large pelvic masses. Subsequent
lung metastases were evident. Then, she received palliative chemotherapy which yielded only partial response as the best response before progression. She died 10 months after diagnosis.

Keywords: Ewing’s sarcoma, uterine cervix, ESWR1 gene rearrangement