Phan Thao Nguyen, MD, PhD¹, Pham Thi Hong Nhung, PhD², Pham Xuan Hieu, MD¹, Nguyen Thi Nguyet, PhD², Nguyen Ngoc Vinh Yen, MD¹, Nguyen The Huy, MD¹, Tran-Thuy Nguyen, MD, PhD¹^,²

Objective: To evaluate the effectiveness of intravenous thrombolysis (IVT), mechanical thrombectomy (MT), and bridging therapy (IVT followed by MT) in Vietnamese patients with acute ischemic stroke.

Materials and Methods: The present study was a longitudinal case series study conducted at E Hospital, Vietnam, between November 2020 and April 2023. Eighty-one patients were included and divided into three groups: IVT alone, MT alone, and bridging therapy. Clinical characteristics, imaging findings, and outcomes were analyzed using chi-square tests, Fisher’s exact test, and logistic regression.

Results: Among 81 patients, 46 (56.8%) were male, and 53 (65.4%) were older than 60 years. Fifty-three patients (65.4%) received IVT only, seven (8.6%) underwent MT only, and 21 (25.9%) received bridging therapy. Hypertension was present in 64.2% of the patients, and 22.2% had a prior history of stroke. At the 3-month follow-up, no significant differences in functional outcomes were observed among the three treatment groups. However, the National Institutes of Health Stroke Scale (NIHSS) score at admission, 24 hours post-intervention, and at discharge differed significantly across groups. In addition, aged over 60 years, NIHSS at 24 hours, and the Alberta Stroke Program Early CT Score (ASPECTS) at 24 hours were significantly associated with 3-month outcomes (p<0.05).

Conclusion: Reperfusion therapies yielded comparable three-month outcomes, while early neurological scores and imaging (NIHSS and ASPECTS at 24 hours) were strong predictors of short-term prognosis.

Received 10 October 2025 | Revised 2 February 2026 | Accepted 3 February 2026

DOI: 10.35755/jmedassocthai.2026.4.03686