The Comparative Study of Diabetic Specific Formula and Standard Formula on Postprandial Plasma Glucose Control in Type 2 DM Patients
Supawan Buranapin MD*, Sanguansak Siangruangsang MD*, Vipawan Chantapanich MD*, Natavuth Hengjeerajarus MD*
Affiliation : * Section of Endocrinology, Department of Internal Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand
Objective : To compare the postprandial plasma glucose level after diabetic specific formula (DSF) and standard formula
(SF) administration in type 2 diabetic patients.
Material and Method: Thirty type 2 diabetic patients were included in the present randomized, controlled, double-blind,
cross-over study. Subjects received DSF and isocaloric SF as a bolus administration of 400 mL while continuing their
anti-diabetic medications. Venous blood samples were collected and analyzed to assess plasma glucose levels at pre- and
at 30, 60, 90, 120, and 180 min post-administration of the formulas.
Results : Postprandial glucose profiles were significantly lower with DSF compared to SF administration determined as a
mean glucose concentration at 2-hour post-administration. The glucose area under the curve (AUC) after DSF consumption
was 33% lower than the AUC after SF consumption, p<0.001.
Conclusion : Use of DSF resulted in a significantly lower postprandial rise in plasma glucose concentrations than using
SF. It should be the preferred option in diabetic patients who need nutritional support.
Keywords : Diabetic specific formula, Postprandial glucose, Type 2 diabetes
