The Difference of Treatment Results between Botulinum Toxin A Split Injection Sites and Botulinum Toxin A Non-Split Injection Sites for Hemifacial Spasm
Anuwat Prutthipongsit MD*, Nipat Aui-aree MD*
Affiliation : * Department of Ophthalmology, Faculty of Medicine, Prince of Songkla University, Hat Yai, Songkhla, Thailand
Objective : To compare hemifacial spasm treatment results between Botulinum toxin A split injection sites and Botulinum
toxin A non-split injection sites.
Material and Method: Thirty-one hemifacial spasm patients were randomly assigned into the non-split injection sites group
(injecting Botulinum toxin A to the zygomaticus major and risorius each) or split injection sites group with the same amount
of Botulinum toxin A as the first method (injection Botulinum toxin A to the zygomaticus major and minor and risorius two
injections each) The main outcomes are onset of improvement and effective duration of treatment.
Results : Fifteen patients were assigned to non-split injection sites group and 16 patients were assigned to split injection
sites group. The median onset of improvement in non-split injection sites group and split injection sites group was 4.0 and
4.5 days, respectively (p = 0.984). The effective duration of treatment in the non-split injection sites group was 60.0 days
and in the split injection sites group was 54.5 days (p = 0.582).
Conclusion : The splitting of injection sites did not significantly improve the efficacy of Botulinum toxin A in the treatment
of hemifacial spasm.
Keywords : Botulinum toxin, Hemifacial spasm, Dysport®
