Rate of Recurrent and Clinicopathologic Features in Cervical Cancer Stage IA2-IB1 after Radical Hysterectomy and Pelvic Lymphadenectomy
Thunnapas Apinuthirunchot MD1, Nungrutai Saeaib MD1, Tippawan Liabsuetrakul MD, PhD2, Kanest Kanjanapradit MD3
Affiliation : 1 Department of Obstetrics and Gynecology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand 2 Epidemiology Unit, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand 3 Department of Pathology, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand
Objective : To determine the rate of recurrent cervical cancer stage IA2-IB1 after radical hysterectomy and pelvic lymphadenectomy
[RHPL], and to explore its clinicopathologic features in association with recurrent rates.
Materials and Methods : A retrospective descriptive study was conducted on patients diagnosed with cervical cancer stages IA2-IB1
after RHPL in Songklanagarind Hospital between January 1, 2004 and December 31, 2012. The demographic data, clinical outcomes,
and pathological factors were collected. The rate of recurrence was calculated in percentage. The exploration of clinicopathologic
features associated with the recurrence was performed by univariate and multivariate analyses.
Results : One hundred thirty-one patients were included in the present study. The recurrence rate was 7.6% without mortality
after two years of follow-ups. The 5-year disease free survival rate was 91.6%. Histology was the signi(cid:976)icant factor for predicting
recurrence of the disease (p = 0.02).
Conclusion : There was still recurrence of the disease in the low-risk group of stage IA2-IB1 cervical cancer even after RHPL. The
histology was the signi(cid:976)icant risk factor associated with recurrent disease.
Keywords : Cervical cancer, Clinicopathologic features, Early stage, Radical hysterectomy, Recurrent disease
