Survivals of Laryngeal Cancer Patients in Thai Military Hospital
Rutti Chumthong MD1, Pariyanan Jarujinda MD1, Ram Rangsin MD2, Ussana Promyothin MD1
Affiliation : 1 Department of Otolaryngology, Phramongkutklao Hospital, Bangkok, Thailand 2 Department of Military medicine, Phramongkutklao Hospital, Bangkok, Thailand
Background : Laryngeal carcinoma is the second most common cancer of head and neck in Thailand. However, the recent information
regarding survival of laryngeal carcinoma in Thailand is limited.
Objective : To describe the survival probability among patients diagnosed with laryngeal carcinoma and to evaluate the factors
affecting the survival rate in the Thai Military hospital.
Materials and Methods: Patients diagnosed with laryngeal carcinoma, e.g., supraglottic, glottic, and subglottic subsited, in
Phramongkutklao Hospital were collected between 2002 and 2012. The study design was retrospective cohort study.
Results : One hundred (cid:976)ifty patients enrolled in the present study. The 5-year overall survival rate of laryngeal carcinoma was
51%. The 5-year survival rate by stages of the disease were stage I 67%, stage II 76%, stage III 59%, and stage IV 36%. The 5-year
disease-free survival in laryngeal carcinoma was 64%. According to the treatment, the overall survival and the disease-free survival
of laryngeal carcinoma in the early stage patients between primary surgery and primary radiation was similar. In the advanced stage
patients, the overall survival with surgery and radiation was higher than the chemoradiation group. Proportional hazards models
showed the decreased survival in poorly differentiated cell type, nodal metastasis, and advanced stage patients without operation.
Conclusion : The study revealed 5-year (overall) survival rate of laryngeal carcinoma was 51%. In the early stage of disease, the
survival rate was the same in both operative and non-operative group, whereas the surgical option had increased the survival rate
signi(cid:976)icantly in the advanced disease. Furthermore, the factors affecting survival rate were cell type and nodal metastasis.
Keywords : Early stage, Advanced stage, Laryngeal carcinoma, Overall survival, Disease-free survival, Chemoradition
