Prompt Treatment of Malignant Hyperthermia during Induction of Anesthesia: Case Report
Sirirat Tribuddharat MD1, Thepakorn Sathitkarnmanee MD1
Affiliation : 1 Department of Anesthesiology, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Malignant hyperthermia [MH] with high mortality is common despite the widespread use of dantrolene. The authors reported a case of a 16-year-old female with congenital lordoscoliosis, scheduled for posterior approach scoliosis surgery, developing MH during induction of anesthesia using fentanyl, propofol, cisatracurium, nitrous oxide, and des(cid:976)lurane. The prompt diagnosis with the aid of capnography was based on clinical symptoms of abrupt tachycardia and hypercapnia. Dantrolene was administered within 15 minutes and continued for 48 hours. Symptoms gradually subsided over the next 15 minutes and the patient recovered uneventfully without signs of rhabdomyolysis. The diagnosis was con(cid:976)irmed by serial serum creatine kinase measurements. The authors suggested that dantrolene should be made available in the operating theater of every hospital.
Keywords : Malignant hyperthermia, Des(cid:976)lurane, Dantrolene, Serum creatine kinase, Hypercarbia
