Perinatal Outcomes of Pregnancy with Anogenital Warts at the Time of Delivery
Rekhawasin T, MD¹, Chayachinda C, MD, MSc¹, Thamkhantho M, MD, FRCOG, MSc¹, Thuwasee T, BNS², Munn A, MD³
Affiliation : ¹ Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ² Department of Nursing, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand ³ Department of Psychiatry, Oregon Health and Science University, Portland, Oregon, USA
Background: Anogenital wart (AGW) is normally more pronounced during pregnancy. However, its impact on perinatal outcomes
remains limited.
Objective: To demonstrate perinatal outcomes in pregnant women with AGWs at the time of delivery.
Materials and Methods: All medical charts of pregnant women with AGWs at the time of delivery at Siriraj Hospital, Mahidol University between January 2007 and December 2016 were reviewed. The characteristics and perinatal outcomes were compared with all deliveries during the same period using inferential statistics.
Results: From the 90,262 deliveries, 490 women (0.54%) with AGWs were included in the present study. The participants’ mean age was 24.5±6.8 years with the GA at 38.0±2.3 weeks. Of them, 70.0% was primigravida and 3.5% had history of AGWs before the current pregnancy. Two thirds were educated to at least high school. Screening for sexually transmitted infections (STIs) showed human immunodeficiency virus (HIV) infection at 5.3%, hepatitis B at 1.6%, and syphilis at 1.2%. The cesarean section rate was 41.6%. Compared with all deliveries during the same period at Siriraj Hospital, Mahidol University, the participants had higher prevalence of LBW (RR 1.39; 95% CI 1.16 to 1.67), VLBW (RR 1.82; 95% CI 1.09 to 3.06), overt DM (RR 2.94; 95% CI 1.32 to 6.55), teenage pregnancy (RR 3.13; 95% CI 2.72 to 3.61), syphilis (RR 6.79; 95% CI 3.02 to 15.27), HIV infection (RR 9.47; 95% CI 6.44 to 13.91), and hepatitis B infection (RR 20.73; 95% CI 10.03 to 42.85).
Conclusion: Pregnant women with AGWs at the time of delivery had a higher risk of having overt DM, concurrent sexually- transmitted infections, and low birth weight newborn.
Received 23 Jan 2020 | Revised 11 Feb 2020 | Accepted 12 Feb 2020
Keywords : anogenital warts, perinatal outcomes, pregnancy
