Prevalence of Symptomatic Venous Thromboembolism in Patients with Malignant Bone and Soft Tissue Tumors Undergo Surgery without Chemoprophylaxis
Woranat Leelacharoenporn MD¹, Winai Sirichativapee MD¹, Taweechok Visanuyotin MD¹, Permsak Paholpak MD¹
Affiliation : ¹ Department of Orthopedics, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand
Background : The prevalence and risk factors of venous thromboembolism (VTE) in malignant bone and soft tissue tumor patients that undergo
surgery is reported in many studies. However, there is lack of studies on the patients without chemoprophylaxis.
Objective : To evaluate the prevalence and risk factors for VTE after surgery in malignant bone and soft tissue tumor patients without chemoprophylaxis Materials and Methods : A retrospective medical chart review identified 260 cases of malignant bone and soft tissue tumor operated between 2008 and 2017. Official diagnostic reports were reviewed from the Picture Archiving and Communication System (PACs). The incidence of VTE and its risk factors were assessed using Chi-square test, t-test, and binary logistic regression.
Results : The overall prevalence of symptomatic VTE was 0.8% (2/260 patients), all of which had PE. No fatal VTE was detected. Asymptomatic pulmonary embolism (PE) was identified in two patients (0.8%) Mean follow up interval of the available data was 9.5 (3 to 36) months. No significant risk factor was found.
Conclusion : The authors found that patients with malignant bone and soft tissue tumors that underwent surgery without chemoprophylaxis in the authors’ center had lower prevalence of VTE when compared to most previous studies whose patient received chemoprophylaxis.
Received 13 April 2020 | Revised 13 June 2020 | Accepted 25 June 2020
doi.org/10.35755/jmedassocthai.2021.05.11226
Keywords : Venous thromboembolism, Sarcoma, Cancer, Deep vein thrombosis, Pulmonary embolism, Thromboprophylaxis, Chemoprophylaxis
