Necrotizing Skin and Soft-Tissue Infections Associated with Septicemia: 7 Cases Report and Review
Sunisa Thaichinda MD*, Narongdet Kositpantawong MD**
Affiliation : * Division of Dermatology, Department of Medicine, Hat Yai Hospital, Songkhla ** Department of Medicine, Hat Yai Hospital, Songkhla
The authors report seven cases of necrotizing skin and soft- tissue infections, with clinical presenting as hemorrhagic bullae, gangrenous cellulitis or necrotizing fasciitis, in association with septicemia, between January 2003 and January 2007 in Hat Yai Hospital. Six were male and the majority of the lesions, six cases, occurred in the lower extremities. The average age of the patients was 50.0 + 11.019 years old. All patients presented with watery diarrhea, severe abdominal pain, high fever and sepsis. The skin lesions were begun with erythema, tender, and swelling with formation of hemorrhagic bullae, gangrene and necrosis within 24- 48 hours. Three of them were caused by Streptococcus spp., another three by Halophilic Vibrios, and only one by Aeromonas hydrophila. Furthermore, the literatures related with clinical manifestations of necrotizing skin and soft-tissue infections, etiologic pathogens, histological finding, management in setting of sepsis, co- morbid conditions, complications and patients’ outcome were reviewed.
Keywords : Necrotizing skin and soft-tissue infections, Hemorrhagic bullae, Gangrenous cellulitis, Necrotizing fasciitis, Septicemia
