Antibiotic Prophylaxis for Orthognathic Surgery: A Prospective, Comparative, Randomized Study between Amoxicillin-Clavulanic Acid and Penicillin
Pornchai Jansisyanont DDS, MS*, Somchai Sessirisombat DDS, MS*, Panunn Sastravaha DDS, MS*, Pimol Bamroong DDS**
Affiliation : * Department of Oral and Maxillofacial Surgery, Faculty of Dentistry, Chulalongkorn University, Bangkok ** Dental Department, Police General Hospital, Bangkok
Objective : The present study was designed to evaluate the prophylactic efficacy after the correction of dentofacial
deformities between short- and long-term penicillin and amoxicillin-clavulanic acid.
Material and Method: The present study was prospective, randomized, and double blinded. Patients were
separated into four groups randomly: short-term and long-term (5 days) penicillin and short-term and long-
term (5 days) amoxicillin-clavulanic acid.
Results : One hundred twenty two patients were assigned randomly into the four groups. Infection developed
in a patient in the short-term amoxicillin-clavulanic acid group and in a patient in the long-term penicillin
group.
Conclusion : There were no differences in infection between the two groups of antibiotics. Based on the present
study, short-term penicillin is still the most appropriate choice for prophylactic antibiotic in orthognathic
surgery.
Keywords : Antibiotic prophylaxis, Orthognathic surgery
