Late Effects and Cosmetic Results of Simultaneous Integrated Boost Versus Sequential Boost after Conventional Irradiation in Breast-Conserving Therapy; Out Come of 7 Months Follow-Up
Tassapong Raiyawa MD*, Chawalit Lertbutsayanukul MD*, Prayuth Rojpornpradit MD*
Affiliation : * Division of Therapeutic Radiology and Oncology, Department of Radiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand
Objective : To compare simultaneous integrated boost and sequential boost after conventional irradiation in
breast-conserving therapy in aspect of late effects and cosmetic results.
Material and Method: Between August 2006 and June 2007, 60 breasts were treated in this prospective non-
randomized study, designed to compare simultaneous integrated boost (additional 10Gy/25F) and sequential
boost (15Gy/5F) to the tumor bed in terms of late effects and cosmetic results at 7-month and 3-year follow-up.
Pearson Chi-square test was used, with an α-value of 0.05.
Results : Hyper/hypopigmentation and induration/fibrosis were commonly seen at 7-months follow-up (p =
0.84 and 0.83, respectively). The cosmetic results were good or excellent.
Conclusion : Although the present study included a small number of patients and short follow-up time, the
preliminary results were comparable between the study groups.
Keywords : Breast neoplasms, Radiation dosage, Radiotherapy dosage, Radiation, Radiation injuries
