Paraoxonase1 Phenotype Distribution in Thais
Sureerut Porntadavity PhD*,+, Soontharee Tantrarongroj MSc*,+, Phanee Pidetcha MSc**, Prabhop Dansethakul MSc*, Lerson Suwannathon BEd*
Affiliation : * Department of Clinical Chemistry, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand ** Central of Medical Service, Faculty of Medical Technology, Mahidol University, Bangkok, Thailand + equally contribution
Objective : To determine the PON1 activity and phenotype distribution in a Thai population.
Study design: Prospective Descriptive study.
Material and Method: Between October 2001 and April 2002, 160 healthy Thai individuals aged 20-74 years
were assessed for PON1 activity and the phenotype distribution by using dual substrate method.
Results : The means + SD of basal, salt-stimulated paraoxonase and arylesterase activities were 239.7 + 83.9
nmol/min/mL 555.2 + 222.2 nmol/min/mL and 147.6 + 33.8 μmol/min/mL respectively. The authors observed
a wide interindividual variability up to 6.9-fold for paraoxonase activity and 4.6-fold for arylesterase activity.
The authors found a range of ssPON/ARE ratio from 1.04 to 7.05 and three distinctive phenotype modals of
AA (1.04-2.25), AB (2.44-4.29), and BB (4.53-7.05) with frequencies of 14.4% (AA), 51.9% (AB), and 33.7%
(BB). The authors also observed the association of sex with lipid parameters and PON1 activity.
Conclusion : The distribution of PON1 phenotype in Thais is clearly trimodal with high frequency in BB
phenotype.
Keywords : Aryldialkylphosphatase, Demography, Paraoxon, Phenotype
