Efficacy of Antimicrobial Coating Suture Coated Polyglactin 910 with Tricosan (Vicryl Plus) Compared with Polyglactin 910 (Vicryl) in Reduced Surgical Site Infection of Appendicitis, Double Blind Randomized Control Trial, Preliminary Safety Report
Chatchai Mingmalairak MD*, Pookate Ungbhakorn MD*, Veeraya Paocharoen MD*
Affiliation : * Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, Thailand
Objective : To evaluate the efficacy and safety of new antibacterial suture (Vicryl Plus) compared with a
traditional braided suture (Vicryl) in a clinical study. The primary goal was to study effectiveness on reduced
surgical site infection in an appendectomy operation. The authors’ secondary goal was to analyze the safety
and physical properties of Vicryl plus.
Material and Method: This was a prospective, randomized, controlled, double blind, comparative, single-
center study. After appendectomy was done, the patients were randomized in two groups: Vicryl Plus and
Vicryl to selected suture for suturing the abdominal sheath. The surgical site infection was evaluated for 30
days, 6 months, and 1 year. The surgeons and attending doctor were blind to the type of suture. This is the
primary report of the first 100 patients.
Results : There was no difference in demographic and preoperative clinical in both groups. Although there
was no statistical difference in the surgical site infection of Vicryl and Vicryl Plus (8 and 10%, p = 0.05), one
case of deep surgical site infection was detected in the Vicryl group. No complications and no difference in
related suture materials were detected.
Conclusion : Coated polyglactin 910 with tricosan (Vicryl Plus) is safe and satisfactory in surgical practice.
Surgical site infection of appendectomy seemed too to be comparable between coated polyglactin 910 with
tricosan (Vicryl Plus) and traditional polyglactin 910 (Vicryl) group.
Keywords : Appendicitis, Appendectomy, Polyglactin 910, Surgical wound infection, Triclosan
