Autologous Chondrocytes Implantation with Three-Dimensional Collagen Scaffold
Channarong Kasemkijwattana MD*, Suraphol Kesprayura MD**, Kanda Chaipinyo PhD***, Cholawish Chanlalit MD*, Kosum Chansiri PhD****
Affiliation : * Department of Orthopedics, Faculty of Medicine, HRH Princess Maha Chakri Sirindhorn Medical Center, Srinakhrinwirot University, Bangkok, Thailand ** Department of Orthopedics, Police General Hospital, Bangkok, Thailand *** Faculty of Health Science, Srinakhrinwirot University, Bangkok, Thailand **** Department of Biochemistry, Faculty of Medicine, Srinakhrinwirot University, Bangkok, Thailand
Objective : The authors report a patient with large traumatic knee cartilage defects treated with autologous
chondrocytes implantation (ACI) in three-dimensional collagen scaffold.
Material and Method: A patient with grade 3-4 according to ICRS (International Cartilage Repair Society)
Classification System was performed ACI with three-dimensional collagen scaffold. The two-stage procedure
was performed. First, the cartilage was arthroscopic harvested. The chondrocytes were isolated in the laboratory.
Second, the chondrocytes were re-implanted into the defects using three-dimensional collagen scaffold. The
patients were clinically evaluated pre-operatively and post operatively and magnetic resonance imaging.
The duration of follow-up was 12 months.
Results : There was no post operative complication. The clinical evaluations were excellent. The MRI showed
the hyaline-like cartilage tissue formation at the defects.
Conclusion : The autologous chondrocytes implantation with three-dimensional collagen scaffold showed
the excellent outcome. Long-term follow-up is required.
Keywords : Knee injury, Autologous chondrocytes implantation, Cartilage defects, Collagen scaffold
