Long-Term Study of Escherichia coli and Klebsiella pneumoniae Isolates Producing Extended-Spectrum Beta-Lactamases
Pitimon Polwichai MSc*, Suwanna Trakulsomboon PhD***, Surang Dejsirilert MSc*, Orathai Thongmali BSc*, Pathom Sawanpanyalert MD, DrPh*, Nalinee Aswapokee MD***, Wanchai Buppanharun MD**
Affiliation : * National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand, ** Division of Preventive Medicine and Social Sciences, Faculty of Medicine, Srinakharinwirot University, Nakorn Nayok, Thailand *** Unit of Infectious Diseases, Faculty of Internal Medicine, Siriraj University Hospital, Mahidol University, Bangkok, Thailand
Objective : To evaluate the prevalence and susceptibility pattern of Escherichia coli and Klebsiella pneumoniae
isolates producing extended-spectrum beta-lactamases (ESBLs) in Thailand from 2000 to 2005.
Material and Method: Data on the WHONET, from 28 hospitals participated in the National Antimicrobial
Resistance Surveillance, Thailand surveillance program, were reviewed and analyzed for the prevalence and
susceptibility pattern.
Results : During the five-year surveillance from 2000 to 2005, the prevalence of ESBL-producing E. coli
detected by ceftazidime screening test was 17%, 21.3%, 23.2%, 20.4%, 23.1%, and 25.0%; as well as detected
by cefotaxime screening test was 20.8%, 65.9%, 69.3%, 69.3%, 68.3%, and 33.8%, respectively. The
prevalence of ESBL-producing K. pneumoniae detected by ceftazidime screening test was 30.9%, 34.7%,
32.5%, 34.4%, 37.2%, and 39.2%; as well as detected by cefotaxime screening test 38.4%, 39.3%, 40.1%,
41.0%, 42.8%, and 40.4%, respectively.
Conclusion : From 2000 to 2005, the prevalence of ESBL-producing organisms in Thailand was high.
ESBL-producing E. coli was most commonly isolated from sputum, followed by blood and urine specimens.
ESBL-producing K. pneumoniae had not been increasingly isolated from sputum, blood, and urine.
Keywords : Escherichia coli, Klebsiella pneumoniae, Beta-lactamases, Thailand
