National Antimicrobial Resistance Surveillance, Thailand (NARST) Data among Clinical Isolates of Pseudomonas aeruginosa in Thailand from 2000 to 2005
Surang Dejsirilert MSc*, Chusana Suankratay MD, PhD**, Suwanna Trakulsomboon PhD***, Orathai Thongmali BSc*, Pathom Sawanpanyalert MD, DrPh*, Nalinee Aswapokee MD, PhD***, Woraphot Tantisiriwat MD, MPH****
Affiliation : * National Institute of Health, Department of Medical Sciences, Nonthaburi, Thailand ** Division of Infectious Diseases, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand *** Unit of Infectious Diseases, Faculty of Internal Medicine, Siriraj University Hospital, Mahidol University, Bangkok, Thailand **** Department of Preventive Medicine, Faculty of Medicine, Srinakharinwirot University, Nakhorn Nayok, Thailand
Objective : To determine the prevalence, clinical epidemiology, and antimicrobial susceptibility of
Pseudomonas aeruginosa in Thailand from 2000 to 2005.
Material and method: Using WHONET data from 28 hospitals participating in the National Antimicrobial
Resistance Surveillance Thailand (NARST) program, all data were reviewed and analyzed for the prevalence,
clinical epidemiology, and antimicrobial susceptibility of clinical isolates of P. aeruginosa from 2000 to 2005.
Results : During the six-year surveillance, the prevalence of P. aeruginosa in clinical isolates was constant
among 28 hospitals. The most common sites of isolation included sputum, pus, and urine. The most active
antimicrobials were netilmicin (88% to 90.8%), cefoperazone/sulbactam (85.1% to 89.5%), imipenem (84.6%
to 87.2%), and meropenem (84.5%). The resistance to ceftazidime was very high, ranging from 24.6-27.4%.
The prevalence of multidrug-resistant (MDR) P. aeruginosa (resistance to amikacin, ciprofloxacin, and
ceftazidime) was constant. Some hospitals in Central and Eastern regions had the prevalence of MDR up to
20% to 30% of the isolates.
Conclusion : According to NARST data, the antimicrobial resistance rates of P. aeruginosa remains constant
with the exception of relatively high rates in ceftazidime. The prevalence of MDR P. aeruginosa is generally
low with a moderately high prevalence in some hospitals.
Keywords : Anti-infective agents, Drug resistance microbial, Microbial sensitivity tests, Population surveillance, Pseudomonas aeruginosa, Thailand
