Effect of Ayurved Siriraj Herbal Recipe Chantaleela on Platelet Aggregation
Rath Itthipanichpong MD*, Arunee Lupreechaset MD*, Sirikul Chotewuttakorn MSc*, Pravit Akarasereenont MD, PhD*,**, Tasanee Onkoksoong BSc*, Titchaporn Palo BSc*, Supornchai Kongpatanakul MD*, Somruedee Chatsiricharoenkul MD*, Premrutai Thitilertdecha BSc**, Prasopporn Punpeng BSc**, Tawee Laohapand MD**
Affiliation : * Department of Pharmacology, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand. ** Center of Applied Thai Traditional Medicine, Faculty of Medicine, Siriraj Hospital, Mahidol University, Bangkok Thailand
Introduction: Ayurved Siriraj Chantaleela recipe is a traditional Thai remedy consisting of eight medicinal
plants, which is employed for the treatment of fever.
Objective : To investigate the effects of Ayurved Siriraj Herbal recipe Chantaleela on platelet aggregation.
Study design: Clinical research; ex vivo with before and after study design.
Material and Method: Twelve healthy male and female volunteers participated in the present study. Platelet
aggregation test before Chantaleela ingestion was done as a control. After administration of 750 mg
Chantaleela (3 x 250 mg tablets) every 8 hours for 3 doses, platelet aggregation was measured 8 hours
following the first dose using an aggregometer and microplate reader. Adrenaline (Adr) and adenosine
diphosphate (ADP) were used as platelet stimulants. Platelet aggregation was measured again at 32 hours
and 8-10 days after the first dose.
Results : All of the participants completed the present study without any adverse event. Ayurved Siriraj
Chantaleela did not affect platelet aggregation; neither Adr nor ADP were used as platelet agonists in both
aggregometer and microplate reader. Subgroup analysis revealed no significant change in platelet aggregation
after Chantaleela administration according to the control for both male and female groups. The same results
were also obtained in other subgroup analysis including hyperaggregation group, hypo-normal aggregation
group.
Conclusion : From the present study, normal dose of Chantaleela for alleviation of fever does not have an effect
on either platelet aggregation or platelet numbers. It may conclude that the present study supports the safety
use of Chantaleela for relieving fever, as platelet status does not need to be taken into consideration.
Keywords : Siriraj Ayurved recipe, Platelet aggregation, Adrenaline, ADP
